TR | EN

Anasayfa : Haberler : Eritroid Stimulan Ajanlar (ESA) Tartışma ve Uyarıları 2008'de de aynı hızla devam ediyor. FDA 3 Ocak 2008 acil uyarısı.

Eritroid Stimulan Ajanlar (ESA) Tartışma ve Uyarıları 2008'de de aynı hızla devam ediyor. FDA 3 Ocak 2008 acil uyarısı.

 FDA News

FOR IMMEDIATE RELEASE
January 3, 2008
       

Media Inquiries:
Karen Riley, 301-827-6244
Consumer Inquiries:
888-INFO-FDA

FDA Receives New Data on Risks of Anemia Drugs
Consistent With Previous Data on Tumor Growth and Death

The U.S. Food and Drug Administration (FDA) is reviewing new data from two studies that provide further evidence of the risks of anemia drugs known as erythropoiesis-stimulating agents, or ESAs. The studies show that patients with breast or advanced cervical cancers who received ESAs to treat anemia caused by chemotherapy died sooner or had more rapid tumor growth than similar patients who didn’t receive the anemia drug.

These two studies were not among the six studies that were described in revised labeling approved by FDA Nov. 8, 2007, which strengthened warnings about ESAs in cancer patients.

Taken together, all eight studies show more rapid tumor growth or shortened survival when patients with breast, non-small cell lung, head and neck, lymphoid or cervical cancers received ESAs compared to patients who did not receive this treatment. In all of these recent studies, ESAs were administered in an attempt to achieve a hemoglobin level of 12 grams per deciliter (g/dL) or greater, although many patients did not reach that level.

FDA plans to discuss this new data and revisit the risks and benefits of using ESAs in patients with chemotherapy-induced anemia at a public advisory committee meeting in the next few months.

“This new information further underscores the safety concerns regarding the use of ESAs in patients with cancer, which FDA addressed in previous communications,” said Janet Woodcock, M.D., FDA's deputy commissioner for scientific and medical programs, chief medical officer, and acting director of the Center for Drug Evaluation and Research.

“FDA is reviewing these data and may take additional action. In the meantime, FDA recommends that health care providers review the risks and benefits of ESAs outlined in the product label and discuss this information with their patients.”

ESAs are a bioengineered version of a natural protein made in the kidney that stimulates the bone marrow to produce more red blood cells.

Physicians determine whether a patient is anemic and decide on ESA dosing by measuring how much of the protein known as hemoglobin is present in a patient's red blood cells, typically expressed in grams per deciliter.

FDA-approved uses of ESAs are for the treatment of anemia in patients with chronic kidney failure; for cancer patients whose anemia is caused by chemotherapy; and for those infected with the human immunodeficiency virus (HIV) whose anemia is caused by the HIV drug AZT (zidovudine). ESAs are also approved to reduce the number of transfusions during and after major surgery.

On Nov. 30, Amgen, manufacturer of the three ESAs -- Aranesp, Epogen, and Procrit -- provided FDA with information from the 733-patient PREPARE study of women who received chemotherapy before undergoing surgery for breast cancer. After three years, 14 percent of the patients who received Aranesp to treat their anemia had died, compared to 9.8 percent who did not receive the drug. Tumor growth was also faster in patients receiving Aranesp.

On Dec. 4, Amgen informed FDA of the results of a study by the National Cancer Institute’s Gynecologic Oncology Group of patients receiving chemotherapy and radiation for advanced cervical cancer. The patients were administered either Procrit to maintain hemoglobin levels above 12 g/dL or blood transfusions as needed. After three years, 66 percent of the patients who did not take Procrit were alive and free of cancer growth compared to 58 percent who had received the drug.

FDA approved revised boxed warnings and other safety-related product labeling changes for ESAs in November and March 2007. Safety concerns regarding ESAs were discussed during advisory committee meetings in 2004 and 2007 and labeling was revised in 1997, 2004 and 2005 to reflect new safety information

 

purchase suprax overnight

suprax sale suprax overnight 400 mg suprax suprax 200 mg

purchase suprax overnight

suprax sale suprax overnight antibiotic suprax suprax 200 mg

purchase suprax overnight

suprax sale suprax overnight suprax cost walgreens suprax 200 mg

purchase suprax overnight

suprax sale suprax overnight http://www.dunshaughlinac.com/news-details.asp?id=112 suprax 200 mg

purchase suprax overnight

suprax sale suprax overnight suprax suprax 200 mg

350,000 problem gamblers

teen gambling http://www.800gambler.org/ council on compulsive gambling of nj, inc.

350,000 problem gamblers

teen gambling gambling hotline council on compulsive gambling of nj, inc.

350,000 problem gamblers

teen gambling 1-800-gambler® council on compulsive gambling of nj, inc.

350,000 problem gamblers

teen gambling http://www.800gambler.org/ council on compulsive gambling of nj, inc.

350,000 problem gamblers

teen gambling 1-800-gambler® council on compulsive gambling of nj, inc.

clarithromycin reviews

buy clarithromycin 250mg buy clarithromycin clarithromycin online

clarithromycin reviews

buy clarithromycin 250mg http://www.geospatialworld.net/Event/View.aspx?EID=63#buyclarithromycin clarithromycin online

clarithromycin reviews

buy clarithromycin 250mg buy biaxin online clarithromycin online

clarithromycin reviews

buy clarithromycin 250mg buy clarithromycin clarithromycin online

clarithromycin reviews

buy clarithromycin 250mg buy clarithromycin clarithromycin online

buy clarithromycin canada

buy biaxin 500mg buy clarithromycin buy biaxin canada

buy clarithromycin canada

buy biaxin 500mg buy clarithromycin buy biaxin canada

buy clarithromycin canada

buy biaxin 500mg order biaxin buy biaxin canada

buy clarithromycin canada

buy biaxin 500mg http://www.geospatialworld.net/Event/View.aspx?EID=63#buyclarithromycin buy biaxin canada

buy clarithromycin canada

buy biaxin 500mg clarithromycin buy biaxin canada

buy discount clarithromycin

clarithromycin online http://www.geospatialworld.net/Event/View.aspx?EID=53 cheapest biaxin

buy discount clarithromycin

clarithromycin online http://www.geospatialworld.net/Event/View.aspx?EID=53 cheapest biaxin

buy discount clarithromycin

clarithromycin online http://www.geospatialworld.net/Event/View.aspx?EID=53 cheapest biaxin

buy discount clarithromycin

clarithromycin online buy biaxin uk cheapest biaxin

buy discount clarithromycin

clarithromycin online buy biaxin uk cheapest biaxin

buy clarithromycin usa

buy clarithromycin australia buy clarithromycin usa cheap biaxin

buy clarithromycin usa

buy clarithromycin australia buy clarithromycin usa cheap biaxin

buy clarithromycin usa

buy clarithromycin australia buy clarithromycin cheap biaxin

buy clarithromycin usa

buy clarithromycin australia buy clarithromycin cheap biaxin

buy clarithromycin usa

buy clarithromycin australia clarithromycin online cheap biaxin

buy clarithromycin no prescription

buy cheap biaxin cheap biaxin buy generic clarithromycin

buy clarithromycin no prescription

buy cheap biaxin buy clarithromycin buy generic clarithromycin

buy clarithromycin no prescription

buy cheap biaxin purchase clarithromycin buy generic clarithromycin

buy clarithromycin no prescription

buy cheap biaxin http://www.geospatialworld.net/Event/View.aspx?EID=63#buyclarithromycin buy generic clarithromycin

buy clarithromycin no prescription

buy cheap biaxin purchase clarithromycin buy generic clarithromycin

where to buy abortion pills online

where can i buy abortion pills cytotec abortion pill buy online buy the abortion pill online

where to buy abortion pills online

where can i buy abortion pills http://sagesoftware.co.in/Default.aspx buy the abortion pill online

where to buy abortion pills online

where can i buy abortion pills http://sagesoftware.co.in/Default.aspx buy the abortion pill online

where to buy abortion pills online

where can i buy abortion pills http://sagesoftware.co.in/Default.aspx buy the abortion pill online

where to buy abortion pills online

where can i buy abortion pills abortion pill buy the abortion pill online

online purchase abortion pill

where can i buy abortion pills http://www.geospatialworld.net/Event/View.aspx?EID=53 order abortion pill online

online purchase abortion pill

where can i buy abortion pills abortion pill order abortion pill online

online purchase abortion pill

where can i buy abortion pills abortion pill order abortion pill online

online purchase abortion pill

where can i buy abortion pills abortion pills order abortion pill online

online purchase abortion pill

where can i buy abortion pills http://www.geospatialworld.net/Event/View.aspx?EID=53 order abortion pill online

how to order the abortion pill online

abortion pill online purchase http://www.cengage.co.in/content/about-us how to order the abortion pill online

how to order the abortion pill online

abortion pill online purchase abortion pill how to order the abortion pill online

how to order the abortion pill online

abortion pill online purchase order abortion pill online how to order the abortion pill online

how to order the abortion pill online

abortion pill online purchase abortion pill how to order the abortion pill online

how to order the abortion pill online

abortion pill online purchase where can you buy the abortion pill how to order the abortion pill online

buy viagra online safe

alternative to viagra viagra kaufen get viagra

buy viagra online safe

alternative to viagra viagra kaufen get viagra

buy viagra online safe

alternative to viagra viagra kaufen get viagra

buy viagra online safe

alternative to viagra free viagra get viagra

buy viagra online safe

alternative to viagra viagra online get viagra

female uk kamagra

cialis vs kamagra mail order kamagra order kamagra online

female uk kamagra

cialis vs kamagra http://www.cengage.co.in/content/terms-of-use order kamagra online

female uk kamagra

cialis vs kamagra buy kamagra on the internet order kamagra online

female uk kamagra

cialis vs kamagra buy levitra online kamagra order kamagra online

female uk kamagra

cialis vs kamagra kamagra order kamagra online

problems with kamagra jelly

buy kamagra jelly in london england kamagra jelly kamagra jelly side effects

problems with kamagra jelly

buy kamagra jelly in london england kamagra jelly sale kamagra jelly side effects

problems with kamagra jelly

buy kamagra jelly in london england buy kamagra jelly on the internet kamagra jelly side effects

problems with kamagra jelly

buy kamagra jelly in london england kamagra jelly sale kamagra jelly side effects

problems with kamagra jelly

buy kamagra jelly in london england kamagra jelly kamagra jelly side effects

generic amoxil

buy cheap amoxil online uk amoxicillin amoxil for sale

generic amoxil

buy cheap amoxil online uk women does amoxicillin work amoxil for sale

generic amoxil

buy cheap amoxil online uk alternative to amoxil amoxil for sale

generic amoxil

buy cheap amoxil online uk women does amoxicillin work amoxil for sale

generic amoxil

buy cheap amoxil online uk amoxicillin amoxil for sale

free synthroid sample

women does synthroid work synthroid synthroid dosage

free synthroid sample

women does synthroid work where to buy thyroxine online synthroid dosage

free synthroid sample

women does synthroid work http://www.cengage.co.in/content/english-language-teaching synthroid dosage

free synthroid sample

women does synthroid work buy thyroxine online synthroid dosage

free synthroid sample

women does synthroid work synthroid synthroid dosage

women does bisacodyl work

natural bisacodyl alternatives laxative get bisacodyl online

women does bisacodyl work

natural bisacodyl alternatives purchase bisacodyl online get bisacodyl online

women does bisacodyl work

natural bisacodyl alternatives http://www.cengage.co.in/content/library-reference get bisacodyl online

women does bisacodyl work

natural bisacodyl alternatives http://www.cengage.co.in/content/library-reference get bisacodyl online

women does bisacodyl work

natural bisacodyl alternatives http://www.cengage.co.in/content/library-reference get bisacodyl online

buy ampicillin online safe

female herbal principen http://www.cengage.co.in/content/competitive-examinations principen for sale

buy ampicillin online safe

female herbal principen get ampicillin avoid prescription principen for sale

buy ampicillin online safe

female herbal principen ampicillin principen for sale

buy ampicillin online safe

female herbal principen ampicillin principen for sale

buy ampicillin online safe

female herbal principen ampicillin principen for sale

buy abortion pill online

pill for abortion online on line abortion pill order abortion pill

buy abortion pill online

pill for abortion online order abortion pill online order abortion pill

buy abortion pill online

pill for abortion online on line abortion pill order abortion pill

buy abortion pill online

pill for abortion online order abortion pill online order abortion pill

buy abortion pill online

pill for abortion online abortion pills order abortion pill

buy clarithromycin australia

discount clarithromycin clarithromycin cheap clarithromycin

buy clarithromycin australia

discount clarithromycin http://www3.umu.se/kultmed/kurswebb/default.aspx?id=29 cheap clarithromycin

buy clarithromycin australia

discount clarithromycin clarithromycin cheap clarithromycin

buy clarithromycin australia

discount clarithromycin buy cheap clarithromycin cheap clarithromycin

buy clarithromycin australia

discount clarithromycin clarithromycin cheap clarithromycin

generic cipro

natural ciprofloxacin http://www.geospatialworld.net/Event/View.aspx?EID=37 buy ciprofloxacin online a href

generic cipro

natural ciprofloxacin fedex generic cipro buy ciprofloxacin online a href

generic cipro

natural ciprofloxacin ciprofloxacin buy ciprofloxacin online a href

generic cipro

natural ciprofloxacin fedex generic cipro buy ciprofloxacin online a href

generic cipro

natural ciprofloxacin buy cheap cipro online uk buy ciprofloxacin online a href

order cleocin

order cleocin http://www.geospatialworld.net/Event/View.aspx?EID=62 cleocin dosage

order cleocin

order cleocin http://www.geospatialworld.net/Event/View.aspx?EID=62 cleocin dosage

order cleocin

order cleocin http://www.geospatialworld.net/Event/View.aspx?EID=62 cleocin dosage

order cleocin

order cleocin buy cleocin cleocin dosage

order cleocin

order cleocin http://www.geospatialworld.net/Event/View.aspx?EID=62 cleocin dosage

dexone uk

free dexone sample dexamethasone order dexone

dexone uk

free dexone sample dexamethasone order dexone

dexone uk

free dexone sample dexamethasone order dexone

dexone uk

free dexone sample http://www.geospatialworld.net/Event/View.aspx?EID=44 order dexone

dexone uk

free dexone sample http://www.geospatialworld.net/Event/View.aspx?EID=44 order dexone

cheap duricef tablets

duricef prescription buy cefadroxil generic Cefadroxil

cheap duricef tablets

duricef prescription buy purchase duricef online generic Cefadroxil

cheap duricef tablets

duricef prescription buy duricef samples generic Cefadroxil

cheap duricef tablets

duricef prescription buy duricef samples generic Cefadroxil

cheap duricef tablets

duricef prescription buy http://www.geospatialworld.net/Event/View.aspx?EID=105 generic Cefadroxil

buy vantin

photos cefpodoxime where to buy vantin online cefpodoxime equivalent

buy vantin

photos cefpodoxime cefpodoxime cefpodoxime equivalent

buy vantin

photos cefpodoxime where to buy vantin online cefpodoxime equivalent

buy vantin

photos cefpodoxime http://www.geospatialworld.net/Event/View.aspx?EID=151 cefpodoxime equivalent

buy vantin

photos cefpodoxime cefpodoxime cefpodoxime equivalent

buy ceftin online

generic cefuroxime sale alternative to ceftin cheap ceftin

buy ceftin online

generic cefuroxime sale cefuroxime cheap ceftin

buy ceftin online

generic cefuroxime sale http://www.geospatialworld.net/Event/View.aspx?EID=154 cheap ceftin

buy ceftin online

generic cefuroxime sale get cefuroxime cheap ceftin

buy ceftin online

generic cefuroxime sale http://www.geospatialworld.net/Event/View.aspx?EID=154 cheap ceftin

ordering abortion pills to be shipped to house

abortion pill online purchase abortion pill buy abortion pills online

ordering abortion pills to be shipped to house

abortion pill online purchase abortion pill buy abortion pills online

ordering abortion pills to be shipped to house

abortion pill online purchase abortion pill buy abortion pills online

ordering abortion pills to be shipped to house

abortion pill online purchase http://ateneobergamo.it/schedaNews.aspx?id=216 buy abortion pills online

ordering abortion pills to be shipped to house

abortion pill online purchase pill for abortion online buy abortion pills online

cheap cephalexin

buy cheap keflex online uk cephalexin cephalexin for sale

cheap cephalexin

buy cheap keflex online uk buy keflex online a href cephalexin for sale

cheap cephalexin

buy cheap keflex online uk keflex for sale cephalexin for sale

cheap cephalexin

buy cheap keflex online uk cephalexin cephalexin for sale

cheap cephalexin

buy cheap keflex online uk cephalexin cephalexin for sale

buy chloromycetin on the internet

photos chloromycetin chloramphenicol chloromycetin samples

buy chloromycetin on the internet

photos chloromycetin chloramphenicol chloromycetin samples

buy chloromycetin on the internet

photos chloromycetin chloramphenicol chloromycetin samples

buy chloromycetin on the internet

photos chloromycetin generic chloromycetin chloromycetin samples

buy chloromycetin on the internet

photos chloromycetin how does chloromycetin work chloromycetin samples

buy abortion pills online

buy abortion pill online abortion pill online purchase ordering abortion pills to be shipped to house

buy abortion pills online

buy abortion pill online abortion pill ordering abortion pills to be shipped to house

buy abortion pills online

buy abortion pill online http://www.fareastjournals.com/journal_detail.aspx?jid=18 ordering abortion pills to be shipped to house

buy abortion pills online

buy abortion pill online http://www.fareastjournals.com/journal_detail.aspx?jid=18 ordering abortion pills to be shipped to house

buy abortion pills online

buy abortion pill online abortion pill ordering abortion pills to be shipped to house

where to buy clavulanate online

alternative to augmentin http://www.fareastjournals.com/journal_detail.aspx?jid=22 generic augmentin online

where to buy clavulanate online

alternative to augmentin get clavulanate avoid prescription generic augmentin online

where to buy clavulanate online

alternative to augmentin augmentin generic augmentin online

where to buy clavulanate online

alternative to augmentin get augmentin online generic augmentin online

where to buy clavulanate online

alternative to augmentin get augmentin online generic augmentin online


DERNEĞİMİZ

Yönetim Kurulu
Denetim ve Disiplin Kurulları
Bilimsel Alt Komiteler
Üyelik
Tüzük
THD Disiplin Yönergesi
Tarihçe
Faaliyet Kitabı

TOPLANTILAR

Kongre ve Kurslar
HEKHEP ve HALKHEP
Türk Hematoloji Okulu
Eğitim Programı
Diğer Toplantılar

ÖDÜL VE DESTEKLER

Hematoloji Tezi Destek Programı
Araştırma Projelerine Destek Programı
Genç Araştırıcılar İçin Yurt Dışı Desteği
Uluslararası Bilimsel Yayınlara Destek ve
Özendirme Programı

Ulusal Kongre Bildiri Ödülü
HAUD Programı
YDUS Başarı Bursu

HABERLER

Haber ve Duyurular
Basında THD
Endüstriden Haberler
TTB Duyuruları

Anasayfa   |  Dernek Hakkında |  İletişim
2018 © Bu sitenin tüm hakları Türk Hematoloji Derneği'ne aittir.
Kullanım Koşulları
LookUs & Online Makale