13.08.2009
CLINICAL TRIALS AND OBSERVATIONS
A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
Jean-Luc Harousseau1, Giovanni Martinelli2, Wieslaw W. Jedrzejczak3, Joseph M. Brandwein4, Dominique Bordessoule5, Tamas Masszi6, Gert J. Ossenkoppele7, Julia A. Alexeeva8, Gernot Beutel9, Johan Maertens10, Maria-Belen Vidriales11, Hervé Dombret12, Xavier Thomas13, Alan K. Burnett14, Tadeusz Robak15, Nuriet K. Khuageva16, Anatoly K. Golenkov17, Elena Tothova18, Lars Mollgard19, Youn C. Park20, Annick Bessems20, Peter De Porre20, Angela J. Howes20, and for the FIGHT-AML-301 Investigators
1 University Hospital Hotel-Dieu, Nantes, France; 2 University of Bologna, Bologna, Italy; 3 Medical University of Warsaw, Warsaw, Poland; 4 Princess Margaret Hospital, Toronto, ON; 5 Centre Hospitalier Universitaire Limoges, Limoges, France, 6 National Medical Center, Budapest, Hungary; 7 Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; 8 St Petersburg City Clinical Hospital, St Petersburg, Russia; 9 Medizinische Hochschule Hannover, Hannover, Germany; 10 UZ Gasthuisberg, Leuven, Belgium; 11 Hospital Universitario de Salamanca, Salamanca, Spain; 12 Hospital Saint-Louis, Paris, France; 13 Hospital Edouard Herriot, Lyon, France; 14 University Hospital of Wales, Cardiff, United Kingdom; 15 Medical University of Lodz and Memorial Copernicus Hospital, Lodz, Poland; 16 S. P. Botkin Moscow City Clinical Hospital, Moscow, Russia; 17 Moscow Regional Clinical Research Institute, Moscow, Russia; 18 Hospital University of PJS, Kosice, Slovak Republic; 19 Karolinska University Hospital, Stockholm, Sweden; and 20 Ortho-Biotech Oncology R&D, a unit of Johnson & Johnson Pharmaceutical Research & Development LLC, Beerse, Belgium
This phase 3, multicenter, open-label study evaluated the efficacy and safety of tipifarnib compared with best supportive care (BSC), including hydroxyurea, as first-line therapy in elderly patients (70 years) with newly diagnosed, de novo, or secondary acute myeloid leukemia. A total of 457 patients were enrolled with 24% 80 years of age or older. Tipifarnib 600 mg orally twice a day was administered for the first 21 consecutive days, in 28-day cycles. The primary endpoint was overall survival. The median survival was 107 days for the tipifarnib arm and 109 days for the BSC arm. The hazard ratio (tipifarnib vs BSC) for overall survival was 1.02 (P value by stratified log-rank test, .843). The complete response rate for tipifarnib in this study (8%) was lower than that observed previously, but with a similar median duration of 8 months. The most frequent grade 3 or 4 adverse events were cytopenias in both arms, slightly more infections (39% vs 33%), and febrile neutropenia (16% vs 10%) seen in the tipifarnib arm. The results of this randomized study showed that tipifarnib treatment did not result in an increased survival compared with BSC, including hydroxyurea. This trial was registered at www.clinicaltrials.gov as #NCT00093990 [ClinicalTrials.gov] .
purchase suprax overnight
suprax sale suprax overnight
400 mg suprax suprax 200 mg
purchase suprax overnight
suprax sale suprax overnight
antibiotic suprax suprax 200 mg
350,000 problem gamblers
teen gambling
1-800-gambler® council on compulsive gambling of nj, inc.
350,000 problem gamblers
teen gambling
gambling council on compulsive gambling of nj, inc.
350,000 problem gamblers
teen gambling
gambling hotline council on compulsive gambling of nj, inc.
350,000 problem gamblers
teen gambling
1-800-gambler® council on compulsive gambling of nj, inc.
buy clarithromycin canada
buy biaxin 500mg
clarithromycin buy biaxin canada
buy clarithromycin canada
buy biaxin 500mg
order biaxin buy biaxin canada
buy clarithromycin canada
buy biaxin 500mg
order biaxin buy biaxin canada
buy discount clarithromycin
clarithromycin online
cheapest biaxin cheapest biaxin
buy clarithromycin no prescription
buy cheap biaxin
cheap biaxin buy generic clarithromycin
buy clarithromycin no prescription
buy cheap biaxin
cheap biaxin buy generic clarithromycin
buy clarithromycin no prescription
buy cheap biaxin
buy clarithromycin buy generic clarithromycin
where to buy abortion pills online
where can i buy abortion pills
order abortion pill buy the abortion pill online
where to buy abortion pills online
where can i buy abortion pills
abortion pill buy the abortion pill online
where to buy abortion pills online
where can i buy abortion pills
order abortion pill buy the abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pill order abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pills order abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pills order abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pill order abortion pill online
how to order the abortion pill online
abortion pill online purchase
abortion pill how to order the abortion pill online
how to order the abortion pill online
abortion pill online purchase
abortion pill how to order the abortion pill online
how to order the abortion pill online
abortion pill online purchase
on line abortion pill how to order the abortion pill online
buy viagra online safe
alternative to viagra
viagra online get viagra
buy viagra online safe
alternative to viagra
viagra online get viagra
female uk kamagra
cialis vs kamagra
kamagra order kamagra online
female uk kamagra
cialis vs kamagra
kamagra order kamagra online
problems with kamagra jelly
buy kamagra jelly in london england
kamagra jelly sale kamagra jelly side effects
generic amoxil
buy cheap amoxil online uk
buy amoxil amoxil for sale
generic amoxil
buy cheap amoxil online uk
amoxicillin amoxil for sale
free synthroid sample
women does synthroid work
synthroid synthroid dosage
women does bisacodyl work
natural bisacodyl alternatives
laxative get bisacodyl online
women does bisacodyl work
natural bisacodyl alternatives
natural laxative get bisacodyl online
buy ampicillin online safe
female herbal principen
ampicillin principen for sale
buy ampicillin online safe
female herbal principen
ampicillin principen for sale
buy ampicillin online safe
female herbal principen
ampicillin principen for sale
buy abortion pill online
pill for abortion online
buy abortion pill order abortion pill
buy abortion pill online
pill for abortion online
buy abortion pill order abortion pill
buy abortion pill online
pill for abortion online
abortion pill order abortion pill
buy clarithromycin australia
discount clarithromycin
clarithromycin cheap clarithromycin
generic cipro
natural ciprofloxacin
cipro uk buy ciprofloxacin online a href
generic cipro
natural ciprofloxacin
cipro uk buy ciprofloxacin online a href
generic cipro
natural ciprofloxacin
ciprofloxacin buy ciprofloxacin online a href
generic cipro
natural ciprofloxacin
ciprofloxacin buy ciprofloxacin online a href
cheap duricef tablets
duricef prescription buy
cefadroxil generic Cefadroxil
cheap duricef tablets
duricef prescription buy
cefadroxil generic Cefadroxil
cheap duricef tablets
duricef prescription buy
duricef online generic Cefadroxil
buy vantin
photos cefpodoxime
cefpodoxime cefpodoxime equivalent
buy vantin
photos cefpodoxime
cefpodoxime cefpodoxime equivalent
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
ordering abortion pills to be shipped to house
abortion pill online purchase
order abortion pill buy abortion pills online
ordering abortion pills to be shipped to house
abortion pill online purchase
abortion pill buy abortion pills online
ordering abortion pills to be shipped to house
abortion pill online purchase
order abortion pill buy abortion pills online
ordering abortion pills to be shipped to house
abortion pill online purchase
order abortion pill buy abortion pills online
cheap cephalexin
buy cheap keflex online uk
cephalexin cephalexin for sale
cheap cephalexin
buy cheap keflex online uk
cephalexin cephalexin for sale
cheap cephalexin
buy cheap keflex online uk
cephalexin cephalexin for sale
buy abortion pills online
buy abortion pill online
abortion pill buy online ordering abortion pills to be shipped to house
buy abortion pills online
buy abortion pill online
abortion pill buy online ordering abortion pills to be shipped to house
where to buy clavulanate online
alternative to augmentin
get augmentin online generic augmentin online
where to buy clavulanate online
alternative to augmentin
augmentin generic augmentin online
where to buy clavulanate online
alternative to augmentin
augmentin generic augmentin online