Turk J Haematol 2016 Dec 12
Current Review Of Iron Overload And Related Complications In Hematopoietic Stem Cell Transplantation.
Atilla E, Toprak SK, Demirer T.
Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload had shown to be related with infections, hepatic sinusoidal obstruction syndrome (SOS), mucositis, liver dysfunction and acute GVHD. Hyperferritinemia causes decreased survival rates in both pre and post transplant setting. Serum ferritin levels, magnetic resonance imaging (MRI) or liver biopsy are diagnostic tools for iron overload. Organ dysfunction due to iron overload may cause high mortality rates and therefore a sufficient iron chelation therapy is recommended in this setting. In this review the management of iron overload in adult HSCT is discussed.
overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload had shown to be related with infections, hepatic sinusoidal obstruction syndrome (SOS), mucositis, liver dysfunction and acute GVHD. Hyperferritinemia causes decreased survival rates in both pre and post transplant setting. Serum ferritin levels, magnetic resonance imaging (MRI) or liver biopsy are diagnostic tools for iron overload. Organ dysfunction due to iron overload may cause high mortality rates and therefore a sufficient iron chelation therapy is recommended in this setting. In this review the management of iron overload in adult HSCT is discussed.