Turk J Haematol 2015 Aug 6

Antibacterial Activities Of Ankaferd Hemostat (ABS) On 'Shiga Toxin Producing Escherichia Coli' And Other Pathogens Significant In Foodborne Diseases.

Koluman A1, Akar N, Haznedaroglu IC.
Ankaferd hemostat (ABS)-induced pharmacological modulation of essential erythroid proteins can cause vital erythroid aggregation via acting on fibrinogen gamma. Topical endoscopic ABS application is effective in the controlling of gastrointestinal system (GI) hemorrhages and/ or infected GI wounds. Escherichia coli (E. coli) O157:H7, the predominant serotype of Enterohemorrhagic Escherichia coli (EHEC), is a cause of both outbreaks and sporadic cases of hemorrhagic colitis. The aim of this study is to search the effects of ABS on six different Shiga Toxigenic Escherichia coli (STEC) serotypes including, O26, O103, O104, O111, O145 and O157. Moreover, the ABS effects on the other pathogens significant in foodborne diseases, such as Salmonella typhimurium, Campylobacter jejuni, and Listeria monocytogenes were also assessed. S. Typhimurium groups were screened using Florescence in situ Hybridization (FISH) technique for survival. The relative efficacy of ABS solutions to achieve significant logaritmic reduction in foodborne pathogens E. coli O157:H7 and nonO157 serogroups and other emerging food borne pathogens are demonstrated in this study. ABS has antibacterial effects. Our present study indicated for the first time that ABS may act against E. coli O157:H7 which is a cause of thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome and hemorrhagic colitis. The interrelationships between colitis, infection, and hemostasis within the context of ABS application should be further investigated in future studies.
ferd hemostat (ABS)-induced pharmacological modulation of essential erythroid proteins can cause vital erythroid aggregation via acting on fibrinogen gamma. Topical endoscopic ABS application is effective in the controlling of gastrointestinal system (GI) hemorrhages and/ or infected GI wounds. Escherichia coli (E. coli) O157:H7, the predominant serotype of Enterohemorrhagic Escherichia coli (EHEC), is a cause of both outbreaks and sporadic cases of hemorrhagic colitis. The aim of this study is to search the effects of ABS on six different Shiga Toxigenic Escherichia coli (STEC) serotypes including, O26, O103, O104, O111, O145 and O157. Moreover, the ABS effects on the other pathogens significant in foodborne diseases, such as Salmonella typhimurium, Campylobacter jejuni, and Listeria monocytogenes were also assessed. S. Typhimurium groups were screened using Florescence in situ Hybridization (FISH) technique for survival. The relative efficacy of ABS solutions to achieve significant logaritmic reduction in foodborne pathogens E. coli O157:H7 and nonO157 serogroups and other emerging food borne pathogens are demonstrated in this study. ABS has antibacterial effects. Our present study indicated for the first time that ABS may act against E. coli O157:H7 which is a cause of thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome and hemorrhagic colitis. The interrelationships between colitis, infection, and hemostasis within the context of ABS application should be further investigated in future studies.