Transfus Apher Sci 2014 Feb;50(1):53-5

A rare but severe complication of filgrastim in a healthy donor: splenic rupture.

Akyol G1, Pala C2, Yildirim A3, Keklika M2, Demir K2, Dortdudak S4, Sivgin S2, Kaynar L2, Esera B2, Unal A2, Cetin M2.
Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.
l="BACKGROUND" NlmCategory="BACKGROUND">Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.

CASE STUDY:

In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.

RESULTS:

She was followed conservatively. One month later the CT scan signs of rupture disappeared.

CONCLUSION:

We must pay attention to this rare but serious adverse event during filgrastim use.

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