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Extramedullary plasmacytoma presenting as a mediastinal mass
Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm without bone marrow involvement or other systemic characteristics of multiple myeloma. Few large-scale clinical studies have been conducted because of the rarity of EMP, especially when it arises from the mediastinum. Herein we report a rare case of solitary mediastinal plasmacytoma with reactive pleural effusion. A 58-year-old female presented with grade 4 dyspnea and dysphagia, with a mediastinal mass observed with on PET. CT-guided biopsy results were suggestive of IgG kappa-type EMP arising from the anterior mediastinum. The patient was treated with local radiotherapy to the mediastinum, and had clinical and radiological response s were good. Radiotherapy is an effective treatment for mediastinal EMP, but a complete workup is mandatory, including PET, as the majority of such masses coexist with multiple myeloma.

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Authors: Arpana Shukla, Vivek Bansal, Ritu Bhutani, Gaurav Kumar, Jai Sharma, Surinder Solanki, Anurag Mehta

Keywords: Ekstramedüller plazmasitom, plazmasitom, mediastinal, radyoterapi

  • Year: 2011
  • Number: 3
  • Referance No: 82687
  • Figure 1. PET/CT shows a 10.3×8.2-cm anterior mediastinal mass (SUV: 2.6), with bilateral pleural effusion and collapse of the left lung. Saggital (A), coronal (B), and axial (C) views
  • Figure 2. Microscopic examination. A. Diffuse sheets of plasma cells (H&E, 100×). B. Plasma cells show abundant eosinophilic cytoplasm, eccentric cartwheel nuclei with mitosis (thick arrow), and para nuclear halos (thin arrow) (H&E, 200×). C and D. Tumor cells show kappa light chain restriction (C), but no lambda restriction (D) (DAB, 200×)

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