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Intramesenteric Steroid Application for Steroid Refractory Gastrointestinal Graft versus Host Disease
Currently, Steroid refractory severe gastrointestinal (GI) GVHD is one of the important complications in patients undergoing allogeneic transplantation and there has been no standard therapeutical approach of disease yet. We report here the results related to the application of intramesenteric steroid in two cases with steroid refractory GI GvHD. In both cases, the frequency and volume of diarrhea were completely resolved soon after intramesenteric methylprednisolone (MP) injection. In conclusion, intra-arterial steroid injection might be an alternative approach especially steroid refractory GI GvHD.

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Authors: Aynur Ugur Bilgin, Pervin Topcuoglu, Tanzer Sancak, Nahide Konuk, Mutlu Arat

Keywords: Steroid dirençli GvHH ve intramezenterik steroid

  • Year: 2012
  • Number: 4
  • Referance No: 57855

  • Figure 3: Volume of diarrhea and the bilirubin level prior to and after regional steroid injection in case 1.
  • Figure 1: Hemophagocytosis in bone marrow aspirate.
  • Figure 1: Well-delimited necrotic skin ulcers.

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